Lifespan

Lifespan

David A. Sinclair, Matthew D. LaPlante

出版社

Atria Books

出版时间

2019-09-09

文件格式

EPUB

文件大小

20.20MB

评分

★★★★★
内容简介

From an acclaimed Harvard professor and one of Time’s most influential people, this paradigm-shifting book shows how almost everything we think we know about aging is wrong, offers a front-row seat to the amazing global effort to slow, stop, and reverse aging, and calls readers to consider a future where aging can be treated. For decades, experts have believed that we are at the mercy of our genes, and that natural damage to our genes—the kind that inevitably happens as we get older—makes us become sick and grow old. But what if everything you think you know about aging is wrong? What if aging is a disease—and that disease is treatable? In Lifespan, one of the world’s foremost experts on aging and genetics reveals a groundbreaking new theory that will forever change the way we think about why we age and what we can do about it. Aging isn’t immutable; we can have far more control over it than we realize. This eye-opening and provocative work takes us to the frontlines of research that is pushing the boundaries on our perceived scientific limitations, revealing incredible breakthroughs—many from Dr. David Sinclair’s own lab—that demonstrate how we can slow down, or even reverse, the genetic clock. The key is activating newly discovered vitality genes—the decedents of an ancient survival circuit that is both the cause of aging and the key to reversing it. Dr. Sinclair shares the emerging technologies and simple lifestyle changes—such as intermittent fasting, cold exposure, and exercising with the right intensity—that have been shown to help lead to longer lives. Lifespan provides a roadmap for taking charge of our own health destiny and a bold new vision for the future when humankind is able to live to be 100 years young.

David Sinclair, PhD, AO is a professor of genetics at Harvard Medical School. One of the leading innovators of his generation, he has been named by Time as “one of the 100 most influential people in the world” and top 50 most influential people in healthcare. He is a board member of the American Federation for Aging Research and has received more than 35 awards for his research...

目录
Introduction: A Grandmother’s Prayer
PART I: WHAT WE KNOW (THE PAST)
1. Viva Primordium
2. The Demented Pianist
3. The Blind Epidemic

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用户评论
空话连篇……就一个建议可行:少吃点东西。另外推荐了三样东西:白藜芦醇,二甲双胍,烟酰胺单核苷酸。除了二甲双胍,另外两种的吸收和利用率都很成问题。整本书还不如他参加Joe Rogan的那期采访的干货多。其实真的内容写篇博文三四页纸就够了,这非死乞白赖凑出本书来。
Youth → broken DNA → genome instability → disruption of DNA packaging and gene regulation (the epigenome) → loss of cell identity → cellular senescence → disease → death
30岁对我来说就够长了,如果生活更精彩些
啰嗦得不行,google了一下information theory of aging 的图片,然后里面搜到一个论文一个图表总结了作者吃什么补剂,lifestyle(间歇性断食,限制碳水,少吃红肉多吃素,锻炼,避免过度暴露于紫外线、X光、CT, 不抽烟,cold exposure, 维持BMI,除了补剂没有什么新意,一查作者果然有不少利益冲突。当然NMN可以通过亲身体验判断下,不过上面这个lifestypd的变量太多,同时变化就没法测NMN的功效了。 https://www.researchgate.net/publication/343562143_The_information_theory_of_aging_Hacking_immortality
听书
Mind-blowing masterpiece!!
废话连篇。总结下来就几句话: (一)节制饮食:参考间歇性饮食,控制热量摄入。多吃蔬菜🥬,少吃红肉(运动时吃)。16:8饮食法-不吃早餐;5:2轻断食法,一周断食两天。 (二)保持运动习惯,阶段性高强度运动。禁食和运动结合更好。引发适度压力来启动身体抗老防卫机制。 (三)偶尔让身体感到寒冷。 (四)推荐了三样东西:白藜芦醇、二甲双胍、烟酰胺单核苷酸NMN。除了二甲双胍,另外两种的吸收和利用率都有问题。
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